Markers of bone and lipid metabolism with eslicarbazepine acetate monotherapy
نویسندگان
چکیده
منابع مشابه
Real‐world data on eslicarbazepine acetate as add‐on to antiepileptic monotherapy
OBJECTIVE To assess retention, tolerability, and safety, efficacy and effects on quality of life (QoL) of eslicarbazepine acetate (ESL) add-on treatment over 6 months in a real-world adult population with partial-onset seizures. METHODS This non-interventional, multicenter, prospective study was performed in eight European countries. Adult patients (n = 247) for whom the physician had decided...
متن کاملConversion to eslicarbazepine acetate monotherapy: A pooled analysis of 2 phase III studies.
OBJECTIVE To assess the efficacy and safety of eslicarbazepine acetate (ESL) monotherapy. METHODS This post hoc pooled analysis of 2 randomized double-blind studies (093-045 and -046) included adults with partial-onset seizures medically uncontrolled by 1 or 2 antiepileptic drugs (AEDs). Following the baseline period (8 weeks), eligible patients were randomized 2:1 to receive ESL 1,600 mg or ...
متن کاملAssessing long-term effects of eslicarbazepine acetate on lipid metabolism profile, sodium values and liver function tests.
INTRODUCTION Older dibenzazepines with a carboxamide substitution have been demonstrated to cause deleterious effects on lipid metabolism profile, as well as frequent hyponatremia. The aim of our study is to assess the effects of eslicarbazepine acetate, a novel AED, on lipid metabolism profile, sodium values and liver function tests, as well as to compare them with previous effects of carbamaz...
متن کاملRegulation of Bone Metabolism
Bone is formed through the processes of endochondral and intramembranous ossification. In endochondral ossification primary mesenchymal cells differentiate to chondrocytes and then are progressively substituted by bone, while in intramembranous ossification mesenchymal stem cells (MSCs) differentiate directly into osteoblasts to form bone. The steps of osteogenic proliferation, differentiation,...
متن کاملeffects of glucocorticoid on bone metabolism markers and bone mineral density in rats.
statement of problem: glucocorticoid-induced osteoporosis is characterized by a decrease in osteoblast numbers and a marked impairment of new bone formation. purpose: the ain of present study was to evaluate the effect of methylprednisolone acetate on bone metabolism and bone mineral density in rats. materials and methods: eighteen male sprague dawley rats (8 weeks old, weighting 180 gm) were r...
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ژورنال
عنوان ژورنال: Epilepsy Research
سال: 2019
ISSN: 0920-1211
DOI: 10.1016/j.eplepsyres.2019.106216